Decreased concentration of drug at the target site is an example of tolerance mechanism.

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Study for the Pharmaceutics Drug Disposition Test. Prepare with flashcards and multiple choice questions, each answer has hints and explanations. Get set for your exam!

Multiple Choice

Decreased concentration of drug at the target site is an example of tolerance mechanism.

Explanation:
Tolerance can arise when the amount of drug reaching the site of action becomes smaller after repeated exposure. Decreased concentration at the target site is the direct outcome of this pharmacokinetic adjustment, leading to less receptor occupancy and a diminished effect. The other ideas would either increase the drug’s effect (increased receptor affinity or increased target sensitivity) or describe a mechanism that could also lower concentration but doesn’t as directly illustrate the observed drop at the site. So the statement best exemplifies a tolerance phenomenon.

Tolerance can arise when the amount of drug reaching the site of action becomes smaller after repeated exposure. Decreased concentration at the target site is the direct outcome of this pharmacokinetic adjustment, leading to less receptor occupancy and a diminished effect. The other ideas would either increase the drug’s effect (increased receptor affinity or increased target sensitivity) or describe a mechanism that could also lower concentration but doesn’t as directly illustrate the observed drop at the site. So the statement best exemplifies a tolerance phenomenon.

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